Figures
Antibody Recognition of RSV F
The prefusion conformation of the respiratory syncytial virus fusion glycoprotein (RSV F) is a major target for the development of vaccines, protective antibodies and small molecules. The potently neutralizing antibody AM14 is unique in its ability to specifically recognize the trimeric, furin-cleaved, prefusion conformation of RSV F. The structure shown is the RSV F protein bound to three AM14 Fabs and three motavizumab Fabs, viewed looking down toward the viral membrane. McLellan et al.
Image Credit: Morgan SA Gilman
Citation: (2015) PLoS Pathogens Issue Image | Vol. 11(7) July 2015. PLoS Pathog 11(7): ev11.i07. https://doi.org/10.1371/image.ppat.v11.i07
Published: July 31, 2015
Copyright: © 2015 Gilman. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The prefusion conformation of the respiratory syncytial virus fusion glycoprotein (RSV F) is a major target for the development of vaccines, protective antibodies and small molecules. The potently neutralizing antibody AM14 is unique in its ability to specifically recognize the trimeric, furin-cleaved, prefusion conformation of RSV F. The structure shown is the RSV F protein bound to three AM14 Fabs and three motavizumab Fabs, viewed looking down toward the viral membrane. McLellan et al.
Image Credit: Morgan SA Gilman