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PLoS Pathogens Issue Image | Vol. 11(9) September 2015

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ADAP2 Restricts RNA Virus Entry.

Interferon stimulated genes (ISGs) target viruses at various stages of their infectious life cycles, including at the earliest stage of viral entry. Here we identify ArfGAP with dual pleckstrin homology (PH) domains 2 (ADAP2) as a gene upregulated by type I IFN treatment in a STAT1-dependent manner. Coyne et al.

Image Credit: Coyne et al.

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ADAP2 Restricts RNA Virus Entry.

Interferon stimulated genes (ISGs) target viruses at various stages of their infectious life cycles, including at the earliest stage of viral entry. Here we identify ArfGAP with dual pleckstrin homology (PH) domains 2 (ADAP2) as a gene upregulated by type I IFN treatment in a STAT1-dependent manner. Coyne et al.

Image Credit: Coyne et al.

https://doi.org/10.1371/image.ppat.v11.i09.g001