Figures
Control of Polo-like kinase protein abundance to ensure flagellum adhesion in trypanosomes
Scanning electron micrograph of Trypanosoma brucei, illustrating the flagellum (pseudo-colored in pink) that adheres to the cell surface. Flagellum-cell body adhesion requires a specialized cytoskeletal structure termed flagellum attachment zone filament. Assembly of this filament requires the Polo-like kinase, whose level is under stringent control. A Cullin4-based ubiquitin ligase targets Polo-like kinase for ubiquitination and degradation after the G1/S cell cycle transition, thereby ensuring flagellum-cell body adhesion. Hu et al.
Image Credit: Ziyin Li and Hung Quang Dang (University of Texas Health Science Center at Houston)
Citation: (2017) PLoS Pathogens Issue Image | Vol. 13(1) January 2017. PLoS Pathog 13(1): ev13.i01. https://doi.org/10.1371/image.ppat.v13.i01
Published: January 31, 2017
Copyright: © 2017 Li and Dang (University of Texas Health Science Center at Houston). This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Scanning electron micrograph of Trypanosoma brucei, illustrating the flagellum (pseudo-colored in pink) that adheres to the cell surface. Flagellum-cell body adhesion requires a specialized cytoskeletal structure termed flagellum attachment zone filament. Assembly of this filament requires the Polo-like kinase, whose level is under stringent control. A Cullin4-based ubiquitin ligase targets Polo-like kinase for ubiquitination and degradation after the G1/S cell cycle transition, thereby ensuring flagellum-cell body adhesion. Hu et al.
Image Credit: Ziyin Li and Hung Quang Dang (University of Texas Health Science Center at Houston)