The BRCT Domain of PARP-1 Is Required for Immunoglobulin Gene Conversion
Figure 8
A model for the role of PARP-1 in GCV and SHM.
PARP-1 increases GCV and decreases high-fidelity repair, although whether this is accomplished by inhibiting high-fidelity repair and thus diverting repair to a mutagenic pathway or by directly promoting GCV is not yet clear.