Evaluation of Excess Significance Bias in Animal Studies of Neurological Diseases
Figure 1
Venn diagrams of the meta-analyses of animal studies of neurological disorders.
We plotted the number of studies with a total sample size of at least 500 animals; those which showed a nominally (p≤0.05) statistically significant effect per fixed-effects synthesis; those that had no evidence of small-study effects; and those that had no evidence of excess significance. The numbers represent the studies that have two or more of the above characteristics according to the respective overlapping areas.