Death and population dynamics affect mutation rate estimates and evolvability under stress in bacteria
Fig 2
Overestimation of mutation rate when there is death.
From simulations of population growth with known death and mutation rate, we estimate the mutation rate using the classical method, which does not take death into account. For each death rate between 0 and 0.95, 1,000 simulations with 24 parallel cultures were performed. For each simulation, we plot the ratio between the computed mutation rate (based on the number of mutants in the final state of the simulations) and the true mutation rate (used as input of the simulations, here 1*10−9 per division). The red lines indicate the median values, the boxes indicate the upper and lower quartiles, and the vertical bars indicate the upper and lower 5 percentiles. Underlying data have been uploaded to Zenodo (10.5281/zenodo.1211765).
