Transcription Initiation Activity Sets Replication Origin Efficiency in Mammalian Cells
Figure 6
Organisation of replication and transcription initiation at promoter-ORIs.
Maps indicate the number and position of the CAGE tags annotated at CpG island promoter-ORIs with unidirectional (A) and with alternative or bidirectional transcriptional activity (B) [37]. Blue and red arrows indicate transcription from the upper or the lower strand, respectively, and brackets show the position of the CpG islands. Graphs show the nascent strand profiles of the arrays hybridised with 300–800 nt preparations along the same regions. Other symbols are like in Figure 2. (C) Analysis of the TSS and nascent strand profiles at the Flna and Tbx15 loci.