A Forward-Genetic Screen and Dynamic Analysis of Lambda Phage Host-Dependencies Reveals an Extensive Interaction Network and a New Anti-Viral Strategy
Figure 1
A large-scale screen to determine the E. coli genes required for phage lambda infection.
(A) Schematic of the screen procedure. All of the strains in the “Keio Collection” were infected with phage lambda. Strains that exhibited significantly fewer or smaller plaques than the K-12 WT control were considered “hits”. (B) The results of the screen, grouped by functional category. The colored boxes indicate the annotation status of the gene and whether it had been previously associated with lambda phage infection (see legend).