A Forward-Genetic Screen and Dynamic Analysis of Lambda Phage Host-Dependencies Reveals an Extensive Interaction Network and a New Anti-Viral Strategy
Figure 2
Schematics of E. coli pathways and networks involved in lambda infection.
The genes found in this screen are highlighted in yellow. (A) The lamB gene and several genes governing its transcriptional regulation. (B) Biosynthesis of the LPS inner core. Several genes shown here were also identified in a screen for T7 phage infectivity (highlighted in green). (C) Several entry points to central carbon metabolism, with corresponding transcriptional regulation. The asterisk indicates that glk was not among the original 57 “hits” found in the screen but is highlighted here because only one small plaque was found in the assay.