A Forward-Genetic Screen and Dynamic Analysis of Lambda Phage Host-Dependencies Reveals an Extensive Interaction Network and a New Anti-Viral Strategy
Figure 3
E. coli growth curves under normal conditions and incubated with lambda phage.
All four replicates are shown with the average displayed as a bolded line. These growth curves have been normalized by growth rate and maximum growth capacity to facilitate comparison between strains (see Materials and Methods). (A) A typical set of K-12 WT uninfected (gray) and infected (blue) growth curves. (B) A sample of infected knockout strain growth curves to demonstrate the variability between strains, with respect to the response to infection. (C) The ΔlamB, ΔmalI, and ΔmalT strain growth curves, which appear in the same pathway (see Figure 2A), also exhibit very similar infected growth dynamics.