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Breast Cancer DNA Methylation Profiles Are Associated with Tumor Size and Alcohol and Folate Intake

Figure 4

There is an opposite trend for direction of association between breast carcinoma CpG methylation and alcohol intake compared to folate intake.

P-values for alcohol intake (g/day) and total dietary folate (µg/day) are plotted versus regression coefficients from locus-by-locus analysis of CpG methylation. Horizontal blue dotted line intercepts the y-axis at 0.05 to illustrate significance (before correction for multiple comparisons). The vertical solid black like intercepts the x-axis at zero to illustrate the contrasting trends. (A) There is a trend toward decreased methylation with increasing alcohol intake. (B) There is a trend toward increased methylation with increasing dietary folate.

Figure 4

doi: https://doi.org/10.1371/journal.pgen.1001043.g004