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Breast Cancer DNA Methylation Profiles Are Associated with Tumor Size and Alcohol and Folate Intake

Figure 5

Probability of methylation class membership is significantly associated with tumor size, patient age, alcohol intake, and dietary folate when controlling for potential confounders in a multinomial logistic regression model.

Results from a multinomial logistic regression plot the probability of methylation class membership versus covariates controlled for age, race, alcohol consumption, total dietary folate, tumor stage (low vs. high), tumor grade, tumor size, estrogen receptor status, and histology. The referent class (methylation class 3) is on the bottom of the plot in blue-green, remaining classes are plotted in numeric order from bottom to top as shown in the legend. (A) Patient age is significantly associated with methylation class membership (Overall Wald P<0.0001), and all methylation classes except class 4 are individually significantly associated with patient age. (B) Alcohol consumption is significantly associated with methylation class membership (Wald P<0.0001), and methylation classes 2, 4, 5, and 8 are individually significantly associated with alcohol intake. (C) √Total dietary folate intake is significantly associated with methylation class membership (Wald P<0.0001), and all methylation classes are individually significantly associated with total dietary folate. (D) Tumor size is significantly associated with methylation class membership (Wald P<0.0001), and all methylation classes except class 4 are individually significantly associated with tumor size.

Figure 5

doi: https://doi.org/10.1371/journal.pgen.1001043.g005