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Genome-Wide Association Study Identifies Nox3 as a Critical Gene for Susceptibility to Noise-Induced Hearing Loss

Fig 6

Topographical analysis of the auditory pathway at different frequencies (post-noise exposure).

Although no significant difference was seen for the DPOAE thresholds (6A), the wild-type controls show a higher wave 1 amplitude (p = 0.010) only at 8 kHz compared to Nox3^het/+ and Nox3^het/Nox3^het (6B). One-way ANOVA (Tukey test for multiple comparisons). * = p < 0.05. Homozygous = Nox3^het/Nox3^het: Heterozygous = Nox3^het/+: Wild-type = C57BL/6JEiJ strain.

doi: https://doi.org/10.1371/journal.pgen.1005094.g006