The authors made an error in analysis, with SNPs being mapped to human genome build hg18 and genes to human genome build hg19. Consequently, there are errors in Table 5, S15 Table, and the accompanying text on pages 9 and 11. Corrected text and tables are provided here.

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Table 5. QTL candidate gene SNPs associated with aggressive prostate cancer in CGEMS GWAS.

https://doi.org/10.1371/journal.pgen.1005127.t001

The third paragraph of the section ‘Analysis of Human Prostate Cancer GWAS Data Reveals That QTL Candidate Gene SNPs Are Associated with Aggressive Prostate Cancer’ should read:

In the study, 1,372 SNPs mapped within a 100 kb radius of the 29 QTL candidate genes were tested in the CGEMS cohort. Analysis of aggressive vs. non-aggressive disease phenotypes were performed as per the comparisons described in Table 4. Correction for multiple testing was performed using permutation testing (n = 10,000 permutations). Fourteen of the 29 candidate genes exhibited evidence for association with clinical characteristics of aggressive prostate cancer (Table 5). Most notably, SNPs in three of the five genes associated with poor clinical outcomes in TCGA (Provisional) and GSE21032 prostate cancer gene expression datasets (CXCL14, ITGAX, and LPCAT2) were all associated with aggressive prostate cancer: For CXCL14, the following SNPs were associated with Gleason score at prostatectomy: rs2547 (permutation P = 0.003; OR = 0.61 [0.43–0.85]), rs2237061 (permutation P = 0.008; OR = 0.61 [0.43–0.88]), rs10515473 (permutation P = 0.002; OR = 0.72 [0.59–0.88]), and rs4463175 (permutation P = 0.003; OR = 1.42 [1.12–1.81]); and the following with metastasis to regional lymph nodes: rs801564 (permutation P = 0.010; OR = 1.05 [1.01–1.09]) and rs2067000 (permutation P = 0.004; OR = 1.05 [1.02–1.09]). For ITGAX, an association was apparent between rs8045738 and Gleason score at prostatectomy (permutation P = 0.005; OR = 1.33 [1.08–1.62]). Finally, for LPCAT2, rs10521319 was associated with distant metastasis (permutation P = 0.009; OR = 1.11 [1.03–1.20]), and rs9302667 (permutation P = 0.003; OR = 1.35 [1.11–1.64]) and rs893260 (permutation P = 0.006; OR = 1.30 [1.07–1.58]) with Gleason score at prostatectomy. Manhattan plots for all relevant genomic regions are shown in S5 Fig. Additionally, haplotypes in LD with these three QTL candidate genes were associated with clinical markers of prostate cancer aggressiveness (S15 Table).