Advertisement

  • Loading metrics

Open Access

Correction

Correction: A homozygous KAT2B variant modulates the clinical phenotype of ADD3 deficiency in humans and flies

  • Sara Gonçalves,
  • Julie Patat,
  • Maria Clara Guida,
  • Noelle Lachaussée,
  • Christelle Arrondel,
  • Martin Helmstädter,
  • Olivia Boyer,
  • Olivier Gribouval,
  • Marie-Claire Gubler,
  • Geraldine Mollet,
  • Marlène Rio,
  • Marina Charbit,
  • Christine Bole-Feysot,
  • Patrick Nitschke,
  • Tobias B. Huber,
  • Patricia G. Wheeler,
  • Devon Haynes,
  • Jane Juusola,
  • Thierry Billette de Villemeur,
  • Caroline Nava,
  • Alexandra Afenjar,
  • Boris Keren,
  • Rolf Bodmer,
  • Corinne Antignac,
  •  [ ... ],
  • Matias Simons
  • [ view all ]
  • [ view less ]
  • Article
  • Metrics
  • Comments
  • Media Coverage

The legends for Figs 4 and 5 do not match. The legend that is shown for Fig 4 should be for Fig 5, and the legend that is shown for Fig 5 should be for Fig 4.

thumbnail
Download:
Fig 4. Effect of adducin-αγ E559Q on Drosophila heart function.

(A-C) M-mode of beating 2-week-old control (yw/Df(2R); A), adducin-αγ WT (B) and adducin-αγ E559Q (C) rescue hearts. Scale bar: 1 second. (D-H) High-speed movies of beating adducin-αγ WT, adducin-αγ E559Q rescue and control hearts were analysed using semi-automated Optical Heartbeat Analysis [46]. For quantification, 8–19 flies were analyzed. Statistical analysis was performed using one-way ANOVA and Tukey’s multiple comparison, except for Arrhythmia index (H; n = 8–19, Mann-Whitney-Wilcoxon). For all panels: ns, non significant, ***p<0.001 (See S1 Table for details on transgenic flies).

https://doi.org/10.1371/journal.pgen.1007748.g001

thumbnail
Download:
Fig 5. Effect of Gcn5 F304S mutation on Drosophila heart function.

(A-C) M-mode kymographs of 1 day old beating hearts of control flies (yw/Df(3L); A) and Gcn5null flies rescued with Gcn5 WT (B) or Gcn5 F304S (C). Scale bar: 1 second. (D-H) High-speed movies of beating hearts were analysed using semi-automated Optical Heartbeat Analysis [46]. For quantification, 8–19 flies were analyzed. Statistical analysis was performed using one-way ANOVA and Tukey’s multiple comparison for all parameters except arrhythmia index (H), which was analysed using Mann-Whitney-Wilcoxon. For all panels: ns, non significant, *p<0.05 **p<0.01, ***p<0.001, ****p<0.0001 (see S1 Table for details on transgenic flies).

https://doi.org/10.1371/journal.pgen.1007748.g002

Consequently, the seventh sentence under the subheading “KAT2B F307S but not ADD3 E659Q causes cardiac defects in Drosophila” is incorrect. The correct sentence is: Both Gcn5 WT and F304S rescue flies showed a reduction in the normal diastolic diameter compared to control flies (Fig 5F), but only for Gcn5 F304S there was a reduction in contractility, measured as fractional shortening (Fig 5G).

In addition, there are formatting inaccuracies in Table 1. Please see the correct Table 1 here.

thumbnail
Download:
Table 1. Clinical phenotype of affected individuals.

https://doi.org/10.1371/journal.pgen.1007748.t001

Reference

  1. 1. Gonçalves S, Patat J, Guida MC, Lachaussée N, Arrondel C, Helmstädter M, et al. (2018) A homozygous KAT2B variant modulates the clinical phenotype of ADD3 deficiency in humans and flies. PLoS Genet 14(5): e1007386. https://doi.org/10.1371/journal.pgen.100738 pmid:29768408

Citation: Gonçalves S, Patat J, Guida MC, Lachaussée N, Arrondel C, Helmstädter M, et al. (2018) Correction: A homozygous KAT2B variant modulates the clinical phenotype of ADD3 deficiency in humans and flies. PLoS Genet 14(10): e1007748. https://doi.org/10.1371/journal.pgen.1007748

Published: October 26, 2018

Copyright: © 2018 Gonçalves et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.