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Evolution of the Aging Brain Transcriptome and Synaptic Regulation

Figure 1

Genome-wide comparison of brain aging in humans, rhesus macaques, and mice.

a. Venn diagram indicating the extent of overlap in age-related gene expression changes between the three species. The size of each circle corresponds to the number of age-related expression changes in each species. b. A group of 154 common aging genes provides an indicator of biological aging in all three species. Shown is a matrix of Pearson correlation coefficients that indicate the degree of overall similarity between any two samples (see Methods). Positively correlated sample pairs are indicated by red and negatively correlated pairs are indicated by blue. The degree of correlation correlates with color intensity. The species and age groups are indicated (Human: young ≤40 years; aged ≥70 years. Rhesus macaque: young 5–6 years; aged 28–31 years. Mouse: young 5 months; aged 30 months).

Figure 1

doi: https://doi.org/10.1371/journal.pone.0003329.g001