Evolution of the Aging Brain Transcriptome and Synaptic Regulation
Figure 2
Age-regulated genes common to humans, rhesus macaques, and mice.
The transcriptional profiles of genes that are age-regulated in all three species were analyzed by hierarchical clustering. Reduced expressed with aging is indicated by a transition from red in the young to blue in the aged, and vice versa. Genes separate into three groups based on whether the direction of age-related changes (i.e., age-upregulated or age-downregulated) is conserved in all three species (category I), changes between mice and rhesus macaques (category II), or changes between rhesus macaques and humans (category III). Also indicated is the evolutionary time of divergence in years for each pair of species based on analysis of protein sequence alignments [37].