Evolution of the Aging Brain Transcriptome and Synaptic Regulation
Figure 4
Neuronal gene ontology groups distinguish the expression profiles of the aging human and mouse cortex.
a. Neuronal gene ontology (GO) groups that are significantly enriched (p-value≤0.005; binomial approximated p-value for a hypergeometric distribution) for age-related expression changes (SAM comparison, FDR≤0.01) were identified. The X-axis represents the percentage of genes in a GO group with age-related up- or down-regulation. Multiple neuronal GO groups are enriched in the human aging profile; while only a few neuronal GO terms appear at less significant thresholds in the mouse aging profile. Age-upregulated and age-downregulated genes are shown separately. b. Number of genes in each GO group that are represented on the mouse and human microarray platforms.