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Evolution of the Aging Brain Transcriptome and Synaptic Regulation

Figure 5

Global repression of genes associated with GABA-mediated inhibitory neurotransmission.

Shown are age-related changes in the expression of genes that mediate major neurotransmitter systems in the cortex of humans, rhesus monkeys, and mice. a. Genes involved in specific neurotransmitters were identified based on membership in the corresponding GO groups. Age-related fold changes in genes with orthologs in all three species and represented on all three microarray platforms are shown for humans, rhesus monkeys, and mice. Gene identities are provided in Table S11. *q-value≤0.01. b. Age-related fold changes for markers of inhibitory neuronal subpopulations. Statistical significance in a specific species (q-value≤0.01) is denoted with an asterisk.

Figure 5

doi: https://doi.org/10.1371/journal.pone.0003329.g005