Genomic Androgen Receptor-Occupied Regions with Different Functions, Defined by Histone Acetylation, Coregulators and Transcriptional Capacity
Figure 7
Schematic model of AROR functions.
Three types of AR/DNA engagements are envisioned. Inactive ARORs represent AR occupying sites of relatively condensed chromatin along with coregulators W & X; these sites may simply be reservoir of AR to be used during dramatic changes in physiological conditions. Poised ARORs represent AR at AcH3 modified sites ready to engage the transcription initiation machinery, but held in check by coregulaters W & Z. Engaged ARORs represent AR actively mediating transcriptional control of target gene(s) by looping across varying genomic distances perhaps assisted by coregulators Y & Z.