A Novel Method for Detection of Phosphorylation in Single Cells by Surface Enhanced Raman Scattering (SERS) using Composite Organic-Inorganic Nanoparticles (COINs)
Figure 1
Characteristics of Composite Organic-Inorganic Nanoparticles COINS.
a) Transmission electron microscopy images of COINs, AOH (left) and BFU (right). b) Spectral signature of AOH COIN (red), BFU COIN (blue) and glass background (black) are indicated as Raman intensity. c) COIN aggregates enhance the Raman signal of SERS particles. The Raman intensity was measured for the dye alone (AO), silver (Ag) silver+dye (Ag+AO) and COIN−AOH and d) BFU [dye alone (BF), silver (Ag), silver+dye (Ag+BF), and (COIN−BFU) respectively. e) Raman intensity signal of COIN compared to the size of COIN cluster measured for AOH (red) and BFU (blue).