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The Danger Is Growing! A New Paradigm for Immune System Activation and Peripheral Tolerance

Figure 8

Percentage of randomly selected immune parameter sets that activate as a function of pathogen growth rate, r.

For this figure we use α_r ∈ [1, 100], 0.99α_r<α₁₇<α_r, 0.1α_r<β_r<0.5α_r, 0.99β_r<β₁₇<β_r, β_r/K_r<μ_r<1.05β_r/K_r, μ_r<μ₁₇<1.01μ_r, K_r ∈[1], [10], K_r<K₁₇<1.01K_r, γ ∈[1], [10], 30α_r (β₁₇/K₁₇−μ₁₇+β_r/K_r−μ_r)/K_r<τ<100α_r (β₁₇/K₁₇−μ₁₇+β_r/K_r−μ_r)/K_r, δ = 1×10⁻¹⁰, v = 1×10⁻¹⁴, and p = 3. Parameter ranges and justifications for parameter relationships are discussed further in Supporting Information S1.

doi: https://doi.org/10.1371/journal.pone.0008112.g008