Distinct Cerebrospinal Fluid Proteomes Differentiate Post-Treatment Lyme Disease from Chronic Fatigue Syndrome
Figure 2
Comparative analysis of individual CFS and nPTLS CSF proteomes.
A) Unsupervised hierarchical clustering of 59 proteins (see Table S3) that are differentially abundant as determined by ANOVA (p<0.01) clearly separates these two disease states with the exception of one nPTLS sample clustering with CFS patient samples. B) Principal Component Analysis (PCA) of CFS and nPTLS samples demonstrates that the CSF proteomes, and by extension of the CNS status, differ between CFS and nPTLS.