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qpure: A Tool to Estimate Tumor Cellularity from Genome-Wide Single-Nucleotide Polymorphism Profiles

Figure 3

Correlations of cellularity estimated by different methods in a pancreatic cancer cohort.

Cellularity was predicted in the pancreatic cohort using 3 methods: pathology review, qpure and deep Ion Torrent sequencing of KRAS. Cellularity predictions are shown in the boxplot (A), the -value was calculated using an ANOVA test to determine whether on average there is difference between the cellularity scores returned by the different methods. The correlation between each method using Spearman’s rank correlation was calculated (B–D). Scatter plots are shown which compare KRAS deep sequencing and qpure estimates (B), qpure and pathology estimates (C), and KRAS deep sequencing and pathology estimates (D).

Figure 3

doi: https://doi.org/10.1371/journal.pone.0045835.g003