Anti-HIV-1 Activity of Elafin Depends on Its Nuclear Localization and Altered Innate Immune Activation in Female Genital Epithelial Cells
Figure 6
Genital ECs from HIV-resistant (HIV-R) commercial sex workers (CSWs) have significantly lower mRNA expression of TLR2, TLR4, and RIG-I.
Relative mRNA expression levels of TLR2, TLR4, and RIG-I in cervical ECs of HIV-S (▪, N = 10) and HIV-R (•, N = 10) were assessed by RT-qPCR. The relative quantity of expression of these genes was normalized against 18S. The data are shown as the mean ± SD. Statistical analysis was performed using ANOVA, with p considered significant when p<0.05.