Design of High-Specificity Nanocarriers by Exploiting Non-Equilibrium Effects in Cancer Cell Targeting
Figure 4
Specificity can be widely varied depending on parameter selection.
(A) The combination of pretargeted drug-delivery protocol and sigmoidal endocytosis exhibits the highest specificity of all combinations examined. ,
, threshold at
. (B) Maximum specificity across all combinations.
,
,
for sigmoidal endocytosis, and
from 200 to 300 sec for pretargeted drug-delivery protocol. Solid lines correspond to
and
. (C) Effects of the overexpression factor
on specificity across drug-delivery protocols for constant endocytosis profile at
,
. The specificity rises sharply at
. (D) Effects of the endocytosis rate
(normalized by
) across drug-delivery protocols for constant endocytosis profile at
,
,
.