Drug-Induced Acute Myocardial Infarction: Identifying ‘Prime Suspects’ from Electronic Healthcare Records-Based Surveillance System
Figure 3
Central role of histamine in drug-induced acute myocardial infarction via Kounis syndrome.
Aside from its direct vasoconstricting and thrombus-generating effects, histamine also potentiates the platelet aggregating response to adrenaline (dotted outline).