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Impact of Morphometry, Myelinization and Synaptic Current Strength on Spike Conduction in Human and Cat Spiral Ganglion Neurons

Figure 10

SGN response to strong and weak synaptic stimuli.

(A) Postsynaptic currents from rat experiments are characterized by amplitude, time to peak and time constant for decay. (B–E) responses of a type I SGN with parameters from Figure 8A are shown for compartments # 1, 3, 5 and 25. Reduction from a typical synaptic current amplitude (B) to threshold (C) caused an essentially longer delay. Including ion current fluctuations (noisy membrane current model, [7]) in all compartments with active channels resulted in sharply synchronized responses for strong stimulation (D) and in late responses with large jitter (E). Compartment 25 is the fifth postsomatic node of Ranvier in the central process and represents the main part of the expected jitter at the proximal axon ending.

Figure 10

doi: https://doi.org/10.1371/journal.pone.0079256.g010