Inhibition of Nutlin-Resistant HDM2 Mutants by Stapled Peptides
Figure 8
Energetic contribution to the differences in the binding free energies (ΔΔGBinding) between wild type HDM2 and alanine mutant variants for binding to the indicated ligands.
Residues contributing > 2 kcal/mol are highlighted in red, and are further depicted in Venn diagram below.