Molecular Dynamics Simulation of the Allosteric Regulation of eIF4A Protein from the Open to Closed State, Induced by ATP and RNA Substrates
Figure 11
Correlation maps and the differences of correlations.
Dynamical cross-correlation maps for (A) the allosteric ATP+eIF4A simulation and (B) the differences of motion correlations between the ATP+RNA+C-eIF4A and ATP+eIF4A equilibrium simulations, with specific sub-regions squared in black for the correlations of the ATP binding and RNA binding regions, in magenta for the correlations of the ATP binding region and the N-domain – C-domain interface, in blue for the correlations of the N-domain RNA binding region and the N-domain – C-domain interface, and in green for the correlations of the C-domain RNA binding region and the N-domain – C-domain interface.