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A New Conversation between Radiology and Pathology-Identifying Microvascular Architecture in Stages of Cirrhosis via Diffraction Enhanced Imaging In Vitro

Figure 4

Illustration and quantification of microvasculature and fibrosis in corresponding stages of cirrhosis.

Macroscopic observations of liver lobe (A1-4) from representative control, fibrotic, cirrhotic and regressive rats, with corresponding DEI vasculature images (B1-4) and fibrosis stained by Sirius-Red (C1-4). The vasculature of control (B1) became more dense at week 6 (B2), further increasing in number at week 10 (B3). After regression for 30 weeks, the number of micro-vessels decreased (B4). The vascular density (D), intercapillary distance (E) and fibrosis area (F) were summarized and expressed as mean ± SD. *p<0.05 compared with control group. #p<0.05 compared with cirrhotic group.

Figure 4

doi: https://doi.org/10.1371/journal.pone.0087957.g004