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In Vitro and In Vivo Activity of a Novel Locked Nucleic Acid (LNA)-Inhibitor-miR-221 against Multiple Myeloma Cells

Figure 2

Antiproliferative effects induced by transient expression of LNA-i-miR-221 in MM cell lines.

Effects on proliferation (A) and BrdU uptake (B) in NCI-H929 cells induced by transient LNA-miR-221 inhibitor (LNA-i-miR-221) transfection compared to scrambled control (LNA-i-miR-NC). C) OPM-2 cell growth inhibition. MM cells not bearing t(4;14): RPMI-8226 (D), KMS12-BM (E) and INA-6 (F) are not affected by transfection with LNA-i-miR-221 as compared to scrambled LNA sequences. Averaged values ±SD from 3 independent experiments.

Figure 2

doi: https://doi.org/10.1371/journal.pone.0089659.g002