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YAP Promotes Ovarian Cancer Cell Tumorigenesis and Is Indicative of a Poor Prognosis for Ovarian Cancer Patients

Figure 5

High YAP and TEAD4 co-expression levels are associated with a poor prognosis with primary human ovarian cancers.

A. IHC results for TEADs expression in human ovarian cancer tissues. Scale bar = 100 μM. B. Associations between YAP/pYAP expressions and TEAD expressions in an ovarian cancer tissue array. C. Associations between YAP and TEAD4 expressions in 45 ovarian cancer samples ranked by Kaplan-Meier survival estimates. D. YAP and TEAD4 co-expression is associated with a poor prognosis with human ovarian cancer. High TEAD expression versus low TEAD4 expression (left), high YAP expression combined with high TEAD4 expression versus other categories (middle), high YAP expression and high TEAD4 expression combined with high β-catanin versus other categories (right).

Figure 5

doi: https://doi.org/10.1371/journal.pone.0091770.g005