Growth Inhibitory, Bactericidal, and Morphostructural Effects of Dehydrocostus Lactone from Magnolia sieboldii Leaves on Antibiotic-Susceptible and -Resistant Strains of Helicobacter pylori
Figure 2
Time-course bactericidal activity.
H. pylori ATCC43504 was cultured in Brucella broth without or with dehydrocostus lactone (DCL) at 1 (4 mg/L), 1.5 (6 mg/L), and 2 times (8 mg/L) the minimal inhibitory concentration. Viable count of H. pylori ATCC43504 was reduced in a concentration- and time-dependant manner. The bacterial strain survived for 48 h in 4 and 6 mg/L of DCL but died at 36 h in 8 mg/L of DCL. The mean values (± SD) for the log number of colony-forming unit (CFU)/mL were plotted.
