Deconvolution of the Gene Expression Profiles of Valuable Banked Blood Specimens for Studying the Prognostic Values of Altered Peripheral Immune Cell Proportions in Cancer Patients
Figure 3
The MHC genes signature identifies two groups with different death and relapse risks.
(A) Heat map of the MHC genes in the NSCLC patients. For the tissue expression dataset for NSCLC, the patients were classified into two MHC-related groups (MHC High and MHC Low) based on the expression intensities of 18 detected MHC genes listed in Table S2, using two-means clustering. The expression intensities of the MHC genes characterize the level of antigen presentation by DCs in the tumor microenvironment. (B) Kaplan-Meier curve for patients stratified into two MHC-related groups. The p value was calculated using the log-rank test. (C) The distribution of relapsing patients in the MHC-related groups. The chi-square test was used to compare the correlation between the level of MHC gene expression and relapse. Two patients were excluded because information about their relapse was unknown.