Lung Fibroblasts from Patients with Idiopathic Pulmonary Fibrosis Exhibit Genome-Wide Differences in DNA Methylation Compared to Fibroblasts from Nonfibrotic Lung
Figure 7
Stability of DNA methylation differences with cell passage.
Three different IPF cell lines (A, B, and C) were assessed at passages 5, 6, and 7, and the DNA methylation for each cell line and each passage was compared. A) Shown are the methylation level of CpG sites 8, 9, and 10 in the upstream segment of the CARD10 promoter for IPF cell lines A and B at serial passage. B) Shown are the methylation levels of CpG sites 7–14 of the MGMT promoter for IPF cell lines A–C at serial passage.