Immune Status, Strain Background, and Anatomic Site of Inoculation Affect Mouse Papillomavirus (MmuPV1) Induction of Exophytic Papillomas or Endophytic Trichoblastomas
Figure 6
Volcano plots of gene array comparisons between dorsal skin trichoblastoma and tail skin papilloma (A), Dorsal Skin Carcinoma vs. Normal Dorsal Skin (B), Normal Dorsal Skin vs. Normal Tail Skin (C), and Tail Papilloma vs. Normal Tail Skin (D) reveal large numbers of significantly dysregulated probe sets (red dots) in all comparisons. Venn diagram illustrates the numbers of probe sets significantly dysregulated (q-value<0.05) when comparing the dorsal trichoblastoma and tail papilloma with normal tissues from the same sites (E) or dorsal trichoblastoma and facial papilloma with normal tissues (F). Twenty-nine common probe sets (26 genes) were uniquely dysregulated when papillomas from either the face or tail were compared to the dorsal trichoblastoma (G). DS, dorsal skin; DL, dorsal lesion; FS, facial skin; FT, facial lesion; TS, tail skin; TL, tail lesion.
