Transpapillary Drug Delivery to the Breast
Figure 8
Biodistribution of 5-FU in plasma and organs in rat.
Ratio of amount of 5-FU in rat organs or plasma (5-FUO/P) and amount of 5-FU in mammary gland (5-FUMG) after topical (nipple), transdermal (breast skin) and intravenous administration. Each value is represented as mean ± SD (n = 3); * is significant in comparison to intravenous injection group. The values are significant at p<0.05, by one-way ANOVA. MP- topical application on the mammary papilla (nipple); TD- transdermal delivery; IV-intravenous injection. The drug was applied on the mammary papilla or on the breast skin for 2 hrs or 6 hrs. In case of disposition studies, the drug was removed after 6 hrs treatment and the drug concentration in the plasma and organs were measured at 12 hrs.