Organization of Enzyme Concentration across the Metabolic Network in Cancer Cells
Fig 3
Global profile of glycolytic enzyme concentrations across all cell lines.
(a) Distribution of cell protein copy (CPC) values for all glycolytic/gluconeogenic proteins across all cell lines. For each protein the median, standard deviations, max, and min are indicated. (b) Probability distribution function of CPC values for all metabolic proteins and the glycolytic/gluconeogenic subset—different subsets are denoted by different colors. Values were binned with a bin difference of 100.2 and the relative frequency, or percentage of values falling into that bin, were plotted. (c) Distribution of 11 glycolytic proteins in a sequential pathway order. Center dot indicates average CPC value for each protein with bars indicating the max and min measurements across all cell lines. (d) Pathway diagram of glycolysis activity. Blue squares indicate branching into other biological pathways, blue hexagons indicate intermediate metabolites, and purple circles indicate reacting enzymes. Size of purple circle is proportional to the average CPC value for that enzyme across all cell lines.
