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Transgenic Rescue of the LARGEmyd Mouse: A LARGE Therapeutic Window?

Fig 1

The LARGE-LV5 transgene restores IIH6 reactivity, and causes marked hyperglycosylation in muscle.

IIH6 western blot of tissue lysates from brain (a) and quadriceps muscle (b) of WT and LARGEmyd mice with or without the LARGE-LV5 transgene (as indicated). β-dystroglycan included as loading control.

Fig 1

doi: https://doi.org/10.1371/journal.pone.0159853.g001