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Correction: Fluorinated Cannabidiol Derivatives: Enhancement of Activity in Mice Models Predictive of Anxiolytic, Antidepressant and Antipsychotic Effects

  • Aviva Breuer,
  • Christeene G. Haj,
  • Manoela V. Fogaça,
  • Felipe V. Gomes,
  • Nicole Rodrigues Silva,
  • João Francisco Pedrazzi,
  • Elaine A. Del Bel,
  • Jaime C. Hallak,
  • José A. Crippa,
  • Antonio W. Zuardi,
  • Raphael Mechoulam,
  • Francisco S. Guimarães
  • Article
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The first step of Fig 2 appears erroneously in the publication as a repetition of Fig 1. The correct Fig 2 should show the oxidation of cannabidiol diacetate to 9-hydroxy-cannabidiol diacetate. Please see the correct Fig 2 here.

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Fig 2. Synthesis of HUF-102(2).

Reagents and conditions: (a) SeO2, t-BuOOH, CH2Cl2, r.t; (b) DAST, CH2Cl2, 0°C.

https://doi.org/10.1371/journal.pone.0162087.g001

Reference

  1. 1. Breuer A, Haj CG, Fogaça MV, Gomes FV, Silva NR, Pedrazzi JF, et al. (2016) Fluorinated Cannabidiol Derivatives: Enhancement of Activity in Mice Models Predictive of Anxiolytic, Antidepressant and Antipsychotic Effects. PLoS ONE 11(7): e0158779. pmid:27416026