The PKC-β selective inhibitor, Enzastaurin, impairs memory in middle-aged rats
Fig 1
ENZ treatment results in a modest impairment on the Morris Water Maze task of hippocampal-dependent reference memory.
ENZ treatment increased the total swim distance only on Day 3 of testing, indicating an impairment in learning and memory. However, there was no significant difference in total swim distance for either Day 1 or 2.