The PKC-β selective inhibitor, Enzastaurin, impairs memory in middle-aged rats
Fig 2
ENZ treatment impairs overnight retention in the Morris Water Maze.
ENZ treatment led to increased swim distance on the first trial of the final testing day, in comparison to the final trial on the previous day. This is indicative of an absence of overnight retention. Comparatively, vehicle treatment led to similar performance for the two trials, indicating that overnight retention was maintained.