Reduction in terminally differentiated T cells in virologically controlled HIV-infected aging patients on long-term antiretroviral therapy
Fig 4
Characterization of early, intermediate, and late stage terminally differentiated CD4+ T cell subsets in HIV-infected patients with controlled viremia on ART.
Frequencies of CD4+ T cell subsets defined by expression patterns of CD28 and CD57 in HIV+ patients and uninfected individuals (A). Frequencies of (B) early stage (CD28+CD57-), (C) intermediate stage (CD28-CD57-), and (D) late stage (CD28-CD57+) cells within the CD4+ T cell population plotted with increasing CD4 T cell counts in HIV+ and UNC. (n = 100 HIV+, n = 75 UNC) (*p<0.05, **p<0.01, ***p<0.001, ****p<0.0001).