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Reduction in terminally differentiated T cells in virologically controlled HIV-infected aging patients on long-term antiretroviral therapy

Fig 5

Characterization of early, intermediate, and late stage terminally differentiated CD8+ T cell subsets in HIV-infected patients with controlled viremia on ART.

Frequencies of CD8+ T cell subsets defined by expression patterns of CD28 and CD57 in HIV+ and UNC (A). Frequencies of early stage (CD28+CD57-) (B), intermediate stage (CD28-CD57-) (C), and late stage (CD28-CD57+) (D) cells within the CD8+ T cell population plotted with increasing CD4 T cell counts in HIV+ and UNC. (n = 100 HIV+, n = 75 UNC) (*p<0.05, **p<0.01, ***p<0.001, ****p<0.0001).

Fig 5

doi: https://doi.org/10.1371/journal.pone.0199101.g005