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Early indicators of intensive care unit bed requirement during the COVID-19 epidemic: A retrospective study in Ile-de-France region, France

Abstract

The aim of our retrospective study was to evaluate the earliest COVID19-related signal to anticipate requirements of intensive care unit (ICU) beds. Although the number of ICU beds is crucial during the COVID-19 epidemic, there is no recognized early indicator to anticipate it. In the Ile-de-France region, from February 20 to May 5, 2020, emergency medical service (EMS) calls and the response provided (ambulances) together the percentage of positive reverse transcriptase polymerase chain reaction (RT-PCR) tests, general practitioner (GP) and emergency department (ED) visits, and hospital admissions of COVID-19 patients were recorded daily and compared to the number of ICU patients. Correlation curve analysis was performed to determine the best correlation coefficient, depending on the number of days the indicator has been shifted. Primary endpoint was the number of ICU patients. EMS calls, percentage of positive RT-PCR tests, ambulances used, ED and GP visits of COVID-19 patients were strongly associated (R2 ranging between 0.79 to 0.99, all P<0.001) with COVID-19 ICU patients with an anticipation delay of 23, 15, 14, 13, and 12 days respectively. Hospitalization did not anticipate ICU bed requirement. A qualitative analysis of the onset of the second wave period of the epidemic (August 1 to September 15, 2020) in the same region provided similar results. The daily number of COVID19-related telephone calls received by the EMS and corresponding dispatch ambulances, and the proportion of positive RT-PCR tests were the earliest indicators of the number of COVID19 patients requiring ICU care during the epidemic crisis, rapidly followed by ED and GP visits. This information may help health authorities to anticipate a future epidemic, including a second wave of COVID19, or decide additional social measures.

Introduction

The COVID-19 pandemic has a high impact on public health in many countries [1]. The medical response has combined all hospital resources, including emergency departments (ED), conventional hospitalization, and intensive care units (ICU). Despite the beginning of the epidemic in China [2], most Western countries were not sufficiently prepared for its intensity and particularly the wave of critically ill patients requiring ICU. Except for some countries which succeeded in early control of epidemic transmission chains (South Korea, Hong Kong) [3, 4], most countries (China, Italy, France, Spain, UK, USA and Brazil) experienced a rapidly diffusing epidemic pattern. It strucked the health care system with a rare violence and threatened possible ICU bed shortage which would have led to additional mortality [57]. Although epidemiological analyses provided accurate early information concerning the progression of the epidemic [8], they were not able to predict its evolution at the peak of the crisis (including the number of ICU beds required). The peak of the crisis depends indeed on collective measures (testing, isolation of infected patients, social distancing, wearing mask, hand washing, and lockdown), which are the only actions with proven efficacy in the absence of proven specific treatment and/or vaccination to date [9]. In France, all patients requiring ICU were admitted in such units, but this result was only obtained by a considerable increase in the number of ICU beds, and inter-regional ICU patient transfers, to avoid overwhelming of local ICUs [10].

The aim of our study was to evaluate what would have been the earliest COVID19-related signals to anticipate ICU beds requirements. Because several days elapsed between the onset of clinical symptoms and worsening in a small proportion of infected patients requiring ICU (estimated around 5%) [11], we hypothesized that such early signals exists and may be helpful for both public health policy or decisions and hospital management. Thus, we investigated the telephone calls received by the emergency medical services (EMS) and the immediate response provided, visits to general practitioners (GP) and emergency department (ED), hospital in-patient admissions, and positive reverse transcriptase polymerase chain reaction (RT-PCR) tests. We think that this analysis could help health care systems to more rapidly adapt to a future epidemic, including a second wave of COVID-19 [12]. These indicators may help health authorities to decide additional measures such as new lockdown or any other preventive measures at the population level.

Material and methods

This study was approved by the Sorbonne Université ethical committee (CER N° 2020–55, Paris, France) which authorized waived informed consent.

The Ile de France Region (12.1 million inhabitants) comprises eight administrative sub-entities, each of them served by a medicalized EMS known as SAMU (Service d’Aide Médicale Urgente). The Paris city and its inner suburbs (6.7 million inhabitants) is covered by 4 SAMUs belonging to the Greater Paris University hospital network APHP (S1 Fig). The individual SAMUs operate identically, use the same health information and management system (Centre d’Appel de Régulation MEdicale Nominal (CARMEN) created in 2010) and provide an adapted answer to calls to “15”, the French toll-free number dedicated to medical emergencies. This service is based on a medical response to emergency calls where an emergency physician decides the appropriate response for each case. Depending on the evaluation of the severity of the case and the circumstances, the phone response may be a medical advice, a home visit of a GP, the dispatch of an ambulance or rescue workers, and, in the most serious cases, sending a mobile intensive care unit (MICU) staffed by an emergency physician sent on scene as a second or a first tier [13]. To cope with the surge of calls during the COVID-19 crisis, the 4 SAMUs involved in the study have increased their response capacity by creating specific procedures for COVID-19-related calls, such as staff increase, dedicated computer stations, interactive voice server, video consultation, sending instructions by SMS. Prehospital EMT and MICU teams were also significantly reinforced. Since January 20, 2020 all calls and patient records related to COVID-19 were identified in their information system and a daily automated activity report was produced.

The primary endpoint was the number of COVID19 patients who were present in ICU in the Ile de France region during the study period (from February 20 to May 5, 2020), excluding patients transferred in other regions. The secondary endpoint was the daily number of new COVID19 patients admitted into ICU. During the study period, APHP staffed a regionalized and dedicated team to ensure that information concerning ICU bed availability was accurate and available in real time (Répertoire Opérationnel des Ressources Ile-de-France; https://www.ror-if.fr/ror/) and could help any physician to rapidly find an ICU bed for a given patient [10]. We collected daily the number of ICU patients from the Système d’Information pour le Suivi des Victimes (SI-VIC) database which provides real time data on the COVID-19 patients hospitalized in French public and private hospitals (https://www.data.gouv.fr) and was activated for COVID-19 epidemic on March 13, 2020. Before that date, the number of ICU patients was collected by a direct centralized survey of the Regional Health Agency. All COVID-19 ICU cases were confirmed by RT-PCR or computed tomographic scan suggestive of SARS-CoV-2 infection.

We studied 6 indicators as they were reliable and accessible on a daily basis: 1) number of emergency calls received by the 4 SAMUs of APHP and diagnosed as suspected COVID19 patients, using the CARMEN database (S1 Table). A clinical protocol was employed, according to the French ministry of health recommendations [14]; 2) number of these patients requiring dispatch of an ambulance (either ordinary or MICU) using the CARMEN database (S1 Table); 3) number of ED visits for a clinically suspected diagnosis of COVID-19 infection in the Ile-de-France Region, using the French OSCOUR® health information system, created in 2004 and which connects all French ED (https://www.data.gouv.fr). 4) the number of COVID-19 diagnoses made by a private network of GPs who performed only emergency visits on a 24 hour and 7 day basis at home (SOS médecins), in the Ile-de-France region (https://www.data.gouv.fr); 5) the number of hospital admission of the COVID19 patients, in the Ile-de-France region; 6) percentage of positive RT-PCR tests for COVID19 in the Ile-de-France region (https://www.data.gouv.fr). Only the percentage of positive results was considered because the availability of biological tests was limited during the early phase of the epidemic. Moreover, during this early phase, only the APHP could perform RT-PCR. Publicly available sources and APHP data warehouse produced data with de-identified information.

Lastly, since these indicators are now used in our region on a routine daily basis, we assessed their value during the onset of the second wave of the COVID-19 epidemic which hits France. Thus, we analysed the period from August 1 to September 15, 2020 to provide an external validation using a second time frame in the same region. Only a qualitative analysis could be performed since data on primary and secondary endpoints are obviously truncated during this very early phase.

Statistical analysis

For each indicator, we determined the onset defined as the first day the indicator became greater than 0, 50% increase, and peak of the curve during the ascension phase. For these three points, we calculated delays as compared to endpoints. We performed correlation curve analysis during the whole study period by plotting (ICU patients at date T) vs (value of the indicator at date T+t) and varying t (time lag expressed as number of days), to determine the best correlation coefficient, depending on the number of days the indicator had been shifted. The primary variable chosen to assess time delay was the correlation curve, and a time lag value ≥ 7 days was considered as an early alert indicator, and ≥ 14 days a very early one. For each indicator, we computed the time-dependant reproduction ratio (R(t)) using a gamma-distributed generation interval distribution with mean 6 days and standard deviation 4 days [15] to verify that they actually behave as coherent indicators of the epidemic.

We retrospectively investigated how these indicators could have been used as tools to anticipate the burden of ICU COVID19 patients. Since the initial capacity of ICU beds was 40% of that reached at the peak of the crisis we decided to fix this 40% threshold as the upper limit for each indicator, as previously reported [16], and half of this threshold (20%) was made the lower acceptable limit, delimiting a red zone above 40%, a green zone below 20% and an orange zone between these two limits. In addition, we also defined the slope for each indicator that correspond to the 40 and 20% of the maximum slope reached during the initial raise, using the same colour-coding.

Data are expressed as medians [interquartile IQR], or number (percentage). Correlation between two variables was assessed using the parametric Pearson test and expressed as a correlation coefficient. A P value of less than 0.05 was considered significant.

Results

The daily number of emergency calls received by the EMS, ambulances sent, GP and ED visits, RT-PCR, and hospital admission in all patients and COVID-19 patients during the study period is shown in S1 Table. The number of ICU beds increased from 1189 to 2945 (248%) and the number of COVID ICU patients ranged from 0 to 2677 (91%). There was a high correlation between the numbers of ICU patients and new ICU COVID19 patients in the Ile-de-France region and in APHP hospitals (R2 = 0.99, P<0.0001 and R2 = 0.96, P<0.0001, respectively). Inter-regional transfers of ICU patients was performed only lately (from April 28 to May 4, 2020) and concern a few proportion of all patients admitted into ICU during the study period (252/2863, 3.9%).

Fig 1 shows the comparison of each indicator to the primary (number of ICU patients) and secondary (number of new ICU patients) endpoints. The number of EMS calls, number of ambulance dispatch, and percentage of positive RT-PCR tests, were very early indicators, followed by diagnosis by GP and admission to the ED (Table 1). Correlation curve analysis is shown in S2 and S3 Figs. Fig 2 shows what happened if a semi-quantitative analysis of these indicators and their respective thresholds and slopes had been applied during the initial phase of the epidemic.

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Fig 1. Evolution of the 6 tested indicators compared to the number of intensive care unit (ICU) patients and number of new ICU patients during the study period (from February 20 to May 5, 2020).

EMS: emergency calls; GP: general practitioner; ED: emergency department; RT-PCR: reverse transcriptase polymerase chain reaction tests.

https://doi.org/10.1371/journal.pone.0241406.g001

thumbnail
Fig 2. Dashboard of the retained indicators (EMS calls, percentage of positive reverse transcriptase polymerase chain (RT-PCR) tests, and general practitioners (GP) visits) and their respective thresholds and slope had been applied during the initial phase of the epidemic.

Since initial capacity of ICU bed was 40% of the one reached at the peak of the crisis, a red zone was defined above this threshold, a green zone below half of this threshold (i.e. 20% of ICU bed maximum capacity), and an orange zone between these two limits. We also defined the slope for each indicator that correspond to the 40 and 20% of the maximum slope reached during the initial raise, using the same colour coding. The first red flags would have occurred on February 24 (slope) and March 4 (threshold) for COVID19 EMS calls, 22 and 13 days before the date of the French lockdown (March 17, 2020).

https://doi.org/10.1371/journal.pone.0241406.g002

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Table 1. Observed delays between each indicator and primary or secondary endpoints.

https://doi.org/10.1371/journal.pone.0241406.t001

The time-dependant reproduction ratio confirmed that the number of EMS calls informed early on the epidemic course (Fig 3). Similar information was obtained from other indicators with delays up to 15 days, indicating that they appropriately and accurately described the evolution of the epidemic.

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Fig 3. Time-dependant reproduction ratio R(t) computed from different sources of information for COVID-19: EMS calls, general practitioner (GP) visits; emergency department (ED) visits, ambulances, and compared to the number of new intensive care unit (ICU) patients.

The vertical bar is the date of the lockdown in France. The effect of the lockdown on transmission was shown almost in real time, crossing the R = 1 threshold 2 days after its adoption and remaining below afterwards. Positive reverse transcriptase polymerase chain test is not included in this figure because it was a percentage and not an absolute number. Hospital admission was not included because it did not anticipate number of ICU patients.

https://doi.org/10.1371/journal.pone.0241406.g003

As an external validation, the onset of the second wave period in the same region provided similar qualitative results (S4 and S5 Figs). EMS calls, percentage of positive RT-PCR tests, ambulances used, ED and GP visits of COVID-19 patients again the number of COVID-19 ICU patients, although anticipation delays could not be calculated because of the censored data of primary and secondary endpoints.

Discussion

The present study shows that five indicators (EMS calls, percentage of positive RT-PCR tests, dispatch ambulances, ED and GP visits) anticipated the burden of ICU patients for at least 7 days during the COVID19 epidemic, the first three by at least 14 days. This result suggests that they could be valuable tools as daily alert signals to set up plan to face the outbreak burden during the initial wave of the epidemic and may possibly also work during the second wave. These results are important since mortality has been reported being correlated to health care resources [17].

Although many studies estimated the number of patients who would have severe COVID-19 [18, 19] and a recent study analysed the emergency calls and ambulance dispatch [13], very few have assessed early signals associated with ICU requirements. These studies investigated internet or social media data [2022]. To our knowledge, no study analysed data from COVID-19 suspected or infected patients [23]. Since several days (estimation 7–12 days) elapse between the onset of clinical symptoms and worsening of clinical status requiring either admission to the hospital or ICU, our hypothesis is that indicators exist that could be easily available on a daily basis, enabling an accurate and anticipated survey of the COVID-19 epidemic. The availability on a defined geographical region rather than a whole country is important since a heterogeneous time and space spread of the SARS-CoV2 virus has been observed in all severely impacted countries.

Among all tested indicators, EMS calls for COVID19 was a very early one. As many countries have this type of health care organization for emergency calls, the use of this signal is widely applicable although political incitation to use this canal for the population to signal COVID19 infection may differ from one country to another. However, once appropriately used this indicator is early and sensitive. The observed delay between EMS calls and admission into ICU concords with those reported for worsening of the disease [24]. Moreover, the medical assessment of emergency calls may be improved by learning from the first wave. The dispatch of ambulances by EMS was also a very early indicator. It should be pointed out that health authorities initially recommended symptomatic patients not to come directly to ED but rather to call the EMS which were instructed to only transport to hospitals patients needing hospital care and to refer others to GP if ambulatory care was needed. The inclusion of MICU ambulances may have also introduced a bias since some of these severe patients were directly admitted into ICU. Consequently, in different EMS systems, we cannot exclude that transport to the ED may behave differently. The importance of EMS as an early indicator of non-infectious medical disaster has already been reported during the 2003 heatwave in France [25].

The third very early indicator was the proportion of positive RT-PCR for COVID19. Many countries as well as the WHO have emphasized the importance of an early detection of the SARS-CoV2 virus by molecular diagnosis [26]. South Korea and Germany in Europe have widely used extensive testing to better control the epidemic [27, 28]. It is therefore not surprising that this test appears as an early indicator for the COVID19 epidemic. Moreover, when testing is performed on a large scale to detect not only infected patients but also contact individuals, the signals provided by positive RT-PCR may occur earlier, which was not the case in France at the time of the first wave. The population tested further evolved with the course of the epidemic, particularly the proportion of positive patients admitted to the hospital. In France, because of initial test shortage, RT-PCR was reserved for hospitalized patients, including ICU patients, and health staff. As the epidemic diminished and RT-PCR availability increased, more tests were performed for outpatients and their respective contacts to decrease epidemic chain transmission in France. In this situation, the positive RT-PCR may become an earlier test, since some additional time elapses (estimated 3–5 days) between contamination and onset of symptoms. Further studies are required to investigate that point.

Other early indicators were the number of COVID19 diagnosis made by GP and ED. As hospitals were seen by patients as potentially dangerous, many of them were not prompted to attend the ED which led to a dramatic decrease in ED visits for any causes in France during the COVID19 epidemic, as previously reported [29]. The use of GP diagnosis is a valuable tool if a national or regional system uploads valuable and structured information in real time. France converted an existing system for an influenza epidemic, to COVID-19 survey [30], but the number of involved GP remained relatively low and, as they are not available 24 hour a day, they could only enrolled a limited number of patients. The French mobile GP network SOS Médecins offers an alternative for our purpose since their members recorded appropriate clinical information concerning COVID-19 patients during the study period. This network has been included in a national process survey of epidemics since many years. Our results can be applicable to other countries when such organization is at work or when alternative and reliable GP based clinical data is collected. In addition, the French health care authorities have now promoted all GPs as key actors in the detection of COVID clusters. Therefore, evaluation and survey of GP visits should certainly become more sensitive.

Hospital admission ended up not being an early indicator of the number of ICU patients. This result concords with previous studies reporting that the delay between hospital admission to admission into ICU is closed to one day [31].

Several limitations of this study should be noted. First, although the sample sizes were large, our observation was limited to one region of France (with a very high population density) and one event and thus extrapolation should be interpreted with caution. Nevertheless, our analysis of the onset of the second wave of the epidemic in the same region provide can be interpreted as a first external validation evidence, although the qualitative threshold initially chosen (Fig 2) should be adjusted, at least for EMS calls (S5 Fig). Second the geographical repartition and population was not identical between some indicators and endpoints (S1 Fig). However, there was a very high correlation between ICU patients in the region and in APHP as the regulation of ICU bed availability was regionalized during the epidemic and based at the APHP. The GP indicator only reflects a particular activity (emergency visits at home) which is not distributed everywhere (less in rural areas) but this was the only accessible GP indicator. Because of biological test shortage, we only looked at the proportion of positive RT-PCR tests but the absolute number should probably be preferred in countries without such limitation. The presence of physicians (telemedicine) and not only emergency medical technicians (EMT) characterizes the French EMS model. Nevertheless, there is no indication suggesting that an EMT-based system using scripts may not lead to comparable results, particularly during an epidemic wave with a high prevalence of the disease. Definition of COVID-19 suspected diagnosis may have slightly varied during the study period in EMS, ED, and GP and between physicians. Admission into ICU has been modified during the study period as intensivists better understood the characteristics of the disease and modified their therapeutic approaches, particularly trying to avoid tracheal intubation [32], and transfers of ICU patients outside the region was performed just before the peak but these transfers occurred during the very last days before the peak and concerned only a low proportion (3.9%) of patients. We did not perform a multivariate analysis for two reasons: 1) the time delay between each indicator and the endpoint (ICU patients) markedly varied and thus a multivariate indicator should not provide an early alert; in contrast, having several indicators with varying time delay provide a series of successive alerts which reinforce each other (Fig 2 and S5 Fig). Lastly, the raw signal of the indicators was sometimes noisy and a more advanced mathematical analysis could improve their performance [33]. Despite these limitations, we consider that our comparisons remain valid and could be adapted to most health systems and potentially to other types of epidemic scheme.

Conclusions

The daily number of COVID19-related telephone calls received by the EMS and corresponding ambulance dispatch, and the proportion of positive RT-PCR were the earliest indicators of the number of COVID19 patients requiring ICU care during the epidemic crisis in the Ile-de-France region, rapidly followed by ED and GP visits. This information may help health authorities to anticipate a future epidemic, including a second wave of COVID19, to monitor lockdown exit and decide additional social measures to better control COVID-19 outbreak.

Supporting information

S1 Fig. The Ile-de-France region.

This French region (12·1 million inhabitants) comprises eight administrative sub-identities, indicated by their number on the map, the town of Paris being 75. In the present study, the numbers of emergency departments (ED) visits, positive reverse transcriptase polymerase chain reaction (RT-PCR) tests, hospital admissions, intensive care unit (ICU) patients, and new ICU patients were obtained from the whole region. A regionalized organization was installed enabling to rapidly find an ICU bed for a given patient wherever the patient was initially admitted. Panel A: Data from emergency medical system (EMS), including emergency calls and dispatch of ambulances were obtained from the Paris city (75) and its inner suburbs which comprise four administrative sub-entities (75, 92, 93, 94) and their respective EMS (6·71 million inhabitants). Panel B: Data from general practitioner (GP, SOS Médecins network) were obtained from the Ile-de-France region but the density of activity of this GP network (expressed as number of annual visits per million inhabitants).is heterogeneous within the Ile-de-France region.

https://doi.org/10.1371/journal.pone.0241406.s001

(TIF)

S2 Fig. Primary endpoint.

Correlation curves of the six tested indicators compared to the number of intensive care unit (ICU) patients during the study period. EMS: emergency calls; GP: general practitioner; ED: emergency department. D: delay (in days) between the two variables. R2: Pearson coefficient of correlation.

https://doi.org/10.1371/journal.pone.0241406.s002

(TIF)

S3 Fig. Secondary endpoint.

Correlation curves of the six tested indicators compared to the number of new intensive care unit (ICU) patients during the study period. EMS: emergency calls; GP: general practitioner; ED: emergency department. D: delay (in days) between the two variables. R2: Pearson coefficient of correlation.

https://doi.org/10.1371/journal.pone.0241406.s003

(TIF)

S4 Fig. Evolution of the 6 tested indicators compared to the number of intensive care unit (ICU) patients and number of new ICU patients during the onset of the second epidemic waver (from August 1 to September 15, 2020).

EMS: emergency calls; GP: general practitioner; ED: emergency department; RT-PCR: reverse transcriptase polymerase chain reaction tests.

https://doi.org/10.1371/journal.pone.0241406.s004

(TIF)

S5 Fig. Dashboard of the retained indicators (EMS calls, percentage of positive reverse transcriptase polymerase chain (RT-PCR) tests, and general practitioners (GP) visits) during the second wave of the epidemic (August 1 to September 15, 2020) using the same definition as in Fig 2.

https://doi.org/10.1371/journal.pone.0241406.s005

(TIF)

S1 Table. Number of emergency calls per day related to COVID-19 patients received by the four emergency medical system (EMS, i.e. SAMU) of the Assistance Publique-Hôpitaux de Paris (APHP) and number of these patients requiring dispatch of an ambulance (either ordinary or mobile intensive care unit (MICU)) from January 27 to September 15, 2020.

https://doi.org/10.1371/journal.pone.0241406.s006

(DOCX)

S2 Table. Median daily number of emergency calls received by the emergency medical system, ambulances sent, general practitioner (GP) visits, emergency department (ED) visits, reverse transcriptase polymerase chain transmission (RT-PCR), and hospital admission in al; patients and COVID-19 patients during the study period.

https://doi.org/10.1371/journal.pone.0241406.s007

(DOCX)

Acknowledgments

We thank Dr. David Baker, DM, FRCA, (Department of Anesthesiology and Critical Care, Hôpital Necker-Enfants Malades, Paris, France) for reviewing the manuscript. The authors are deeply grateful to Audrey Bourdette, Arthur Cornet, Alban Jourdain, Côme Cheritel, and Henri Matalon from the Data science team, Department of Strategy and transformation at APHP (Paris, France) for their essential assistance for data collection, analysis, editing of figures and statistical analysis. We thank Pr. Laurent Tréluyer (Department of informatics and computer sciences, APHP, Paris, France) for providing us data and Dr. Christophe Leroy (APHP, Paris, France) for valuable discussion. List of investigators by alphabetical order: Prof. Frédéric Adnet (Université Paris 13, Institut National de la Santé et de la Recherche Médicale [INSERM], SAMU 93, Assistance Publique-Hôpitaux de Paris [APHP], Bobigny, France); Marin Boyet (Institut National de la Recherche en Informatique et en Automatique [INRIA], Ecole polytechnique, and Centre National de la Recherche Scientifique [CNRS], Paris, France); Dr. Jean-Jacques Avrane (SOS médecins, Paris, France); Prof. Frédéric Batteux (Université de Paris and APHP, Paris, France); Prof. Pierre-Yves Boëlle (Sorbonne Université, INSERM, and APHP, Paris, France); Dr. Jérémie Boutet (SAMU 92, APHP, Garches, France) Prof. Vincent Calvez (Sorbonne Université, INSERM, and APHP, Paris, France); Prof Pierre Carli (SAMU zonal, APHP and Université de Paris, Paris, France); Dr. Pascal Chansard (SOS Médecins, Paris, France); Dr. Charlotte Chollet (SAMU 94, APHP, Créteil, France); François Crémieux (Deputy CEO, APHP, Paris, France); Pr. Diane Descamps (Université de Paris, INSERM, and APHP, Paris, France); Prof. Stéphane Gaubert (INRIA, Ecole polytechnique, and CNRS, Paris, France); Dr. Laurent Goix (SAMU 93, APHP, Bobigny, France); Pr. Pierre Hausfater (Sorbonne Université and APHP, Paris, France); Martin Hirsch (CEO APHP, Paris, France); Dr. Eric Lecarpentier (SAMU 94, APHP, Créteil, France); Dr. Thomas Loeb (SAMU 92, APHP, Garches, France); Dr. Jean-Sébastien Marx (SAMU 75, APHP, Paris, France); Prof. Catherine Paugam (Université de Paris, INSERM, and APHP, Clichy, France); Prof. Renaud Piarroux (Sorbonne Université, INSERM, and APHP, Paris, France); Prof. Bruno Riou (Sorbonne Université, INSERM, and APHP, Paris, France); Prof. Remi Salomon (Université de Paris and APHP, Paris, France); Dr. Serge Smadja (SOS Médecins, Paris, France); Dr. Caroline Telion (SAMU 75, APHP, Paris, France); Prof. Antoine Vieillard-Baron (Université Versailles St Quentin and Yvelynes and APHP, Boulogne, France).

References

  1. 1. Kandel N, Chungong S, Omaar A, Xing J. Health security capacities in the context of COVID-19 outbreak: an analysis of International Health Regulations annual report data from 182 countries. Lancet 2020;395(10229):1047–53. pmid:32199075
  2. 2. Huang C, Wang Y, Li X, Li X, Ren L, Zhao J, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020;395(10223):497–506. pmid:31986264
  3. 3. Shim E, Tariq A, Choi W, Lee Y, Chowell G. Transmission potential and severity of COVID-19 in South Korea. Int J Infect Dis 2020;93:339–44. pmid:32198088
  4. 4. Cowling BJ, Ali ST, Ng TWY, Tsang TK, Li JCM, Fong MW, et al. Impact assessment of non-pharmaceutical interventions against coronavirus disease 2019 and influenza in Hong Kong: an observational study. Lancet Public Health 2020;5(5):e279–88. pmid:32311320
  5. 5. Kinross P, Suetens C, Gomes Dias J, Alexakis L, Wijermans A, Colzani E, et al. Rapidly increasing cumulative incidence of coronavirus disease (COVID-19) in the European Union/European Economic Area and the United Kingdom, 1 January to 15 March 2020. Euro Surveill 2020;25(11):2000285. pmid:32186277
  6. 6. Grasselli G, Zangrillo A, Zanella A, Antonelli M, Cabrini L, Castelli A, et al. Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy region, Italy. JAMA 2020;323(16):1574–81. pmid:32250385
  7. 7. Richardson S, Hirsch JS, Narasimhan M,, Crawford JM, McGinn T, Davidson KW; et al. Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York city area. JAMA 2020;323(20):2052–9. pmid:32320003
  8. 8. Salje H, Tran Kiem C, Lefrancq N, Courtejoie N, Bosetti P, Paireau J, et al. Estimation of the burden of SARS-CoV2 in France. Science 2020;367(6500):208–11. pmid:32404476
  9. 9. Pan A, Liu L, Wang C, Guo H, Hao X, Wang Q, et al. Association of public health interventions with the epidemiology of the COVID-19 outbreak in Wuhan, China. JAMA 2020;323(19):1–9. pmid:32275295
  10. 10. The COVID19-APHP Group. Assistance Publique-Hôpitaux de Paris’ response to the COVID-19 pandemic. Lancet 2020:395(10239):1760–1. pmid:32464114
  11. 11. Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med 2020;382(18):1708–20. pmid:32109013
  12. 12. Leung K, Wu JT, Liu D, Leung GM. First-wave COVID-19 transmissibility and severity in China outside Hubei after control measures, and second-wave scenario planning: a modelling impact assessment. Lancet 2020;395(10233):1382–1393. pmid:32277878
  13. 13. Lapostolle F, Goix L, Vianu I, Chanzy E, De Stefano C, Gorlicki J, et al. COVID-19 epidemic in the Seine-Saint Denis department of Greater Paris: one month and three waves for a tsunami. Eur J Emerg Med 2020;27(4):274–8. pmid:32516161
  14. 14. Coopération opérationnelle Risque Epidémiologique et Biologique (COREB). Repérer et prendre en charge un patient suspect COVID-19. Information pour les SAMU et autres soignants de 1ère ligne (29 février 2020). https://clicktime.symantec.com/3W8uTBVxJ9XWW5UX9PgWwPr6H2?u=https%3A%2F%2Fwww.coreb.infectiologie.com%2FUserFiles%2FFile%2Fprocedures%2F20200229-covid19-fichesoignants29fev.pdf (Late access September 21, 2020).
  15. 15. Cauchemez S, Boëlle PY, Thomas G, Valleron AJ. Estimating in real time the efficacy of measures to control emerging communicable diseases. Am J Epidemiol 2006;164(6):591–7. pmid:16887892
  16. 16. Tuite AR, Fisman DN, Greer AL. Mathematical modelling of COVID-19 transmission and mitigation strategies in the population of Ontario, Canada. CMAJ 2020;192(19):E497–505. pmid:32269018
  17. 17. Ji Y, Ma Z, Peppelenbosch MP, Pan Q. Potential association between COVID-19 mortality and health-care resource availability. Lancet Global Health 2020;8(4):e480. pmid:32109372
  18. 18. Moghadas SM, Shoukat A, Fitzpatrick MC, Wells CR, Sah P, Pandey A, et al. Projecting hospital utilization during the COVID-19 outbreaks in the United States. Proc Natl Acad Sci USA 2020;117(16):9122–6. pmid:32245814
  19. 19. Li R, Rivers C, Tan Q, Murray MB, Toner E, Lipsitch M. Estimated demand for US hospital inpatient and intensive care unit beds for patients with COVID-19 based on comparisons with Wuhan and Guangzhou, China. JAMA Netw Open 2020;3(5):e20829. pmid:32374400
  20. 20. Li C, Chen LJ, Chen X, Zhang M, Pang CP, Chen H. Retrospective analysis of the possibility of predicting the COVID-19 outbreak from Internet searches and social media data, China, 2020. Euro Surveill 2020; 25(10): ES.2020.25.10.2000199. pmid:32183935
  21. 21. Ayyoubzadeh SM, Ayyoubzadeh SM, Zahedi H, Ahmadi M, R Niakan Kalhori S. Predicting COVID-19 incidence through analysis of Google trends data in Iran: Data mining and deep learning pilot study. JMIR Public Health Surveill 2020;6(2):e18828. pmid:32234709
  22. 22. Qin L, Sun Q, Wang Y, Wu KF, Chen M, Shia BC, et al. Prediction of number of cases of 2019 novel coronavirus (COVID-19) using social media search index. Int J Environ Res Public Health 2020;17(7):E2365. pmid:32244425
  23. 23. Institute of Social and Preventive Medicine. Living evidence on COVID-19 2020. https://ispmbern.github.io/covid-19/living-review/index.html (Accessed May 18, 2020).
  24. 24. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020;395(10229):1054–62. pmid:32171076
  25. 25. Lapostolle F, Fleury M, Crocheton N, Galinski M, Cupa M, Lapandry C, et al. Determination of early markers of a sanitary event. The example of the heat wave of August 2003 at the Samu 93-centre 15 in France. Presse Med 2005;34(3):199–202. pmid:15798529
  26. 26. World Health Organization. Responding to community spread of COVID-19. Interim guidance 7 March 2020. https://apps.who.int/iris/handle/10665/331421 (accessed May 18, 2020).
  27. 27. Kim H. The sociopolitical context of the COVID-19 response in South Korea. BMJ Global Health 2020; 5: e002714. pmid:32404471
  28. 28. Corman VM, Landt O, Kaiser M, Molenkamp R, Meijer A, Chu DK, et al. Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR. Euro Surveill 2020;25(3):2000045. pmid:31992387
  29. 29. Wong LE, Hawkins JE, Langness S, Murrell KL, Iris P, Sammann A. Where are all the patients? Addressing COVID-19 fear to encourage sick patients to seek emergency care. NEJM Catalyst 2020; May 14. https://catalyst.nejm.org/doi/full/10.1056/CAT.20.0193 (accessed May 18, 2020).
  30. 30. Boëlle PY, Souty C, Launay T, Guerrisi C, Turbelin C, Behillil S, et al. Excess cases of influenza-like illnesses synchronous with coronavirus disease (COVID-19) epidemic, France, March 2020. Euro Surveill. 2020;25(14):2000326. pmid:32290901
  31. 31. Phua J, Weng L, Ling L, Egi M, Lim CM, Divatia JV, et al. Intensive care management of coronavirus disease 2019 (COVID-19): challenges and recommendations. Lancet Respir Med 2020;8(5):506–517. pmid:32272080
  32. 32. Oranger M, Gonzalez-Bermejo J, Dacosta-Noble P, Llontop C, Guerder A, Trosini-Desert V, et al. Preliminary report of continuous airway positive pressure to avoid intubation in SARS-CoV2 pneumonia: a two-period retrospective case-controlled study. Eur Respir J 2020;5 (2):2001692.
  33. 33. Gaubert S, Akian M, Allamigeon X, Boyet M, Colin B, Grohens T, et al. Understanding and monitoring the evolution of the Covid-19 epidemic from medical emergency calls: The example of Paris. C R Acad Sci Mathematics (Paris) in press.