Figures
NOX2 staining around the rim of a spongiform vacuole in prion disease.
NOX2 staining in brown, nuclei staining in blue. Spongiform vacuolation is a highly characteristic sign of prion disease pathology, and vacuoles represent distended intracellular compartments mostly located within neuronal processes. A very striking pattern of NOX2 expression around neuronal vacuoles can be detected in brains of patients affected by Creutzfeld-Jakob disease. Data from Adriano Aguzzi and colleagues suggest that NOX2 is a major source of reactive oxygen species in prion diseases, and can affect prion pathogenesis.
Image Credit: Silvia Sorce et al
Citation: (2014) PLoS Pathogens Issue Image | Vol. 10(12) December 2014. PLoS Pathog 10(12): ev10.i12. https://doi.org/10.1371/image.ppat.v10.i12
Published: December 18, 2014
Copyright: © 2014 Sorce et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
NOX2 staining in brown, nuclei staining in blue. Spongiform vacuolation is a highly characteristic sign of prion disease pathology, and vacuoles represent distended intracellular compartments mostly located within neuronal processes. A very striking pattern of NOX2 expression around neuronal vacuoles can be detected in brains of patients affected by Creutzfeld-Jakob disease. Data from Adriano Aguzzi and colleagues suggest that NOX2 is a major source of reactive oxygen species in prion diseases, and can affect prion pathogenesis.
Image Credit: Silvia Sorce et al