Figures
ABHD5 Taps into Lipid Droplets to Support HCV Production
Hepatitis C virus (HCV) particles closely mimic human very-low-density lipoproteins (VLDL) to evade humoral immunity and to facilitate cell entry. However, the principles that govern HCV association with VLDL components are poorly defined. Using an siRNA screen, we identified ABHD5 (a/b hydrolase domain containing protein 5, also known as CGI-58) as a new host factor promoting both virus assembly and release. Vieyres et al.
Image Credit: Vieyres et al.
Citation: (2016) PLoS Pathogens Issue Image | Vol. 12(4) April 2016. PLoS Pathog 12(4): ev12.i04. https://doi.org/10.1371/image.ppat.v12.i04
Published: April 29, 2016
Copyright: © 2016 Vieyres et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Hepatitis C virus (HCV) particles closely mimic human very-low-density lipoproteins (VLDL) to evade humoral immunity and to facilitate cell entry. However, the principles that govern HCV association with VLDL components are poorly defined. Using an siRNA screen, we identified ABHD5 (a/b hydrolase domain containing protein 5, also known as CGI-58) as a new host factor promoting both virus assembly and release. Vieyres et al.
Image Credit: Vieyres et al.