Circular Permutation in Proteins
Figure 2
Two proteins that are related by a circular permutation.
Concanavalin A (left), from the Protein Data Bank (PDB), 3cna and peanut lectin (right), from PDB 2pel, which is homologous to favin. The termini of the proteins are highlighted by blue and green spheres, and the sequence of residues is indicated by the gradient from blue (N-terminus) to green (C-terminus). The 3D fold of the two proteins is highly similar; however, the N- and C- termini are located on different positions of the protein [1].
