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Relating Cortical Atrophy in Temporal Lobe Epilepsy with Graph Diffusion-Based Network Models

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TLE-no case, Model 1: (a) Cortical/subcortical atrophy obtained from t-statistics of epileptic and healthy groups’ volumetrics. (b) R vs. the number of eigen-modes Eq (10) used for neuronal atrophy estimation. (c) Atrophy distribution estimated using Model 1 and eigen-modes u2u27. Model 2: (d) Correlation R of group atrophy and Φ2 obtained when each node is seeded. (e) R vs. graph diffusion depth t. Left paracentral gives the maximum R, followed by the left post central and the left frontal pole. (f) Neuronal atrophy estimate obtained from Model 2 when the paracentral lobe is seeded.

Fig 3

doi: https://doi.org/10.1371/journal.pcbi.1004564.g003